Dr. Bruce Freedman
Plastic Surgery Associates of Northern Virginia

Topical Antioxidants


Bruce M. Freedman, MD, FACS

Background: Microdermabrasion has been accepted as a reliable, non-invasive method for facial rejuvenation. Recently, there has been interest in combining this technique with other modalities to increase its efficacy. The purpose of this study was to determine whether the addition of an antioxidant rich serum enhanced the dermatologic changes seen following microdermabrasion.

Method: Ten female volunteers, ages 38-52, underwent a series of six diamond tip crystal free microdermabrasion facial treatments spaced 7-10 days apart. An antioxidant rich serum was applied to half the face immediately after each microdermabrasion treatment. Skin biopsies, photographs and skin antioxidant levels, determined by Raman Spectroscopy, were obtained prior to and after the study period.

Results: Compared to the microdermabrasion only treated skin, the microdermabrasion and antioxidant treated skin demonstrated significantly increased epidermal and papillary dermal thickness (P<.05). There was increased hyalinization of the papillary dermis with newly deposited collagen fibers. Skin antioxidant levels increased 30% in the skin treated with antioxidant serum after microdermabrasion (P<.05). These changes were supported photographically and by patient survey.

Conclusion: The addition of an antioxidant rich serum to a facial microdermabrasion regimen enhanced the clinical and histologic changes seen following microdermabrasion alone. This combination should strengthen the use of microdermabrasion as a non-invasive facial rejuvenation tool and support the role of topical antioxidants as anti-ageing factors..


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